CD4 and allergic rhinitis: We previously constructed an efficacious murine model of allergic rhinitis, in which systemically primed BALB/c mice showed nasal allergic symptoms such as sneezes and marked elevation of serum antigen-specific IgE level as well as Th2 cytokine production from CD4+ T cells in spleen and CLN after 14 consecutive nasal challenges with antigen [12].