Nomura et al. [8] found that ezetimibe could inhibit the hepatic NPC1Ll activity, reduce the production of reactive oxygen species, suppress the JNK activity, reduce the unfolded or misfolded protein induced endoplasmic reticulum stress, promote the phosphorylation of PI-3K/AKT in the insulin signaling pathway, and then improve the insulin resistance in the liver. This evidence concerns the gene MAPK8 and Insulin resistance.