Amongst people with Alzheimer disease and their family carers, there was variation in perceptions of the benefits of acetylcholinesterase inhibitors, with some studies reporting that medication gave people hope [48],[71],[97],[111],[121],[152], one study reporting that patients and their carers felt that the benefits were not clear but they were “worth a try” [71], and two studies reporting that patients felt medication had little to offer them [62],[106]. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.