Although the exact mechanism by which hyperglycemia causes vascular disruption in retinopathy is not clear, it has been reported that, in addition to triggering oxidative stress along with inflammatory components [6], hyperglycemia is involved in the development of diabetic retinopathy by increasing the activity of aldose reductase (AR) [7] and protein kinase C (PKC) [8], as well as promoting nonenzymatic glycation and glycooxidation of proteins (AGEs) [9]. This evidence concerns the gene AKR1B1 and Hyperglycemia.