In the present study, we demonstrate that SAV-3 infections induce mRNA transcripts of genes including IFN-α and its stimulated genes (ISG) at early time, followed by IFN-γ, TNF-α, IL-12, IL-10, IL-8, CD3ε, CD4, CD8, TCR-α, MHC-I, and MHC-II as the infection progresses. This evidence concerns the gene CD4 and infection.