Of the remaining 64 women diagnosed at ages 36 through 50 years, but with no family history of breast or ovarian cancer, 47 women were screened for germline mutations in BRCA1 and BRCA2 genes, and three BRCA1 and one BRCA2 carriers were identified (mutation prevalence, 8.5%). The gene discussed is BRCA2; the disease is ovarian cancer.