BRCA1 and ovarian carcinoma: However, we find that although TNBC is associated with an increased prevalence of BRCA1 and BRCA2 mutations among those younger than 35 years old (28.0% in TNBC versus 9.9% in non-TNBC; P = 0.045], TNBC is not associated with an increased prevalence of mutations among those aged 36 to 50 years without a family history of breast or ovarian cancer (BRCA prevalence of 8.5% and 6.7%, respectively).