BRCA1 and ovarian carcinoma: Of the remaining 127 women, 63 had already been analyzed because of family history of either breast and/or ovarian cancer (38 individuals, 13 BRCA1 and three BRCA2 carriers, mutation prevalence, 42.1%) or early-onset breast cancer (25 individuals, seven BRCA1 and no BRCA2 carriers; mutation prevalence, 28.0%].