Taken together, we suggest that TNBC status may be helpful in stratifying women with a moderate risk of having BRCA1 mutations (for example, a weak family history or isolated case of early-onset breast cancer), but may have limited utility in the absence of such features (for example, women with a single case of TNBC aged 40 to 50 years old). This evidence concerns the gene BRCA1 and breast cancer.