Since Kalirin has been implicated in early onset cardiovascular disease [39], resting blood pressure was evaluated in WT and KalSRKO/KO mice; no significant differences were observed in this parameter, but Fanaroff et al. [5] have reported a role for Kalrn in smooth muscle cell migration/proliferation and atherogenesis (Figure 5A). Here, KALRN is linked to cardiovascular disorder.