Since it has been reported that DDX11 plays an important role in maintaining fidelity of chromosome arm cohesion prior to mitosis[11], we next determined in a total of 40 chromosome spreads prepared from the DDX11 siRNA-transfected and likewise, the control siRNA-transfected melanoma cells, the number of chromosomes that had closed, partially closed, or open/separated arms. The gene discussed is DDX11; the disease is melanoma.