Melanoma cells that as demonstrated in Figure 4C, panel a, had been transfected for 48 hr with 75 nM of the pool of four control siRNAs, did not reveal any TUNEL staining, but melanoma cells that had received the DDX11 siRNA clearly exhibited apoptosis as reflected by strong TUNEL staining (Figure 4C, panel b). Here, DDX11 is linked to melanoma.