Compared with the DAPI-stained chromosome spreads of melanoma cells that had been transfected for 24 hr with the control siRNA pool (Figure 3A, panel a), the DAPI-stained chromosome spreads of DDX11 siRNA-transfected melanoma cells (Figure 3A, panel b) revealed a pattern of tightly condensed chromosomes. The gene discussed is DDX11; the disease is melanoma.