Second, we describe for the first time that LXRα mRNA transcription induced by its ligand is inhibited by 15dPGJ2 in a fashion similar to other model pro-inflammatory molecules, such as IL-8, TNFα and IL-1, which inhibit LXR transcription in human neutrophils, as similar manner as its do on Hep3B human hepatoma cells [68]. The gene discussed is NR1H3; the disease is hepatocellular carcinoma.