SYN1 and neuroblastoma: In the case of RV, alterations in the actin-based cytoskeleton have been described in the neuroblastoma cells by Ceccaldi et al. (1997), who found that the nucleocapsid of the virus had no direct action on the kinetics of actin polymerization, but could inhibit the actin-binding effect induced by dephosphorylated synapsin I (Bloom et al., 2003; Ceccaldi et al., 1997; Valtorta et al., 1992).