In this regard, it is well accepted that the aberrant glycosylation on the mucin domain of α-dystroglycan, a member of the dystrophin-associated glycoprotein (DAG) complex[39,40], is associated with many forms of muscular dystrophy[40-43], commonly referred to as Dystroglycanopathies[44-46]. This evidence concerns the gene DAG1 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.