Univariate analysis identified lymph node metastasis, hormone receptor status, elevated preoperative CEA level (>5.1 ng/mL), tumor size, nuclear grade, lymphatic involvement and VEGFR-1 mRNA expression levels as adverse prognostic factors for OS (P <0.05 for each factor). The gene discussed is FLT1; the disease is metastatic malignant neoplasm in the lymph nodes.