Multivariate analysis also indicated that high VEGFR-1 mRNA expression was an independent factor for OS (relative risk (RR), 2.00; 95% CI, 1.19 to 3.25, P <0.01), as well as lymph node metastasis (RR, 2.67; 95% CI, 1.53 to 4.96, P <0.001) and hormone receptor status (RR, 2.65; 95% CI, 1.62 to 4.43, P <0.001). This evidence concerns the gene NR4A1 and metastatic malignant neoplasm in the lymph nodes.