The rapid onset and progression of atherosclerosis, CHD, and early death in hypercholesterolemic SR-BI/apoE dKO mice fed a normal chow diet [4], [5] and HypoE mice fed a standard Paigen [6] or Paigen NC (this study) diet can be advantageous for a variety of studies of atherosclerotic CHD. This evidence concerns the gene APOE and coronary artery disorder.