Based on the Dukes stage, seven of total 44 CRC patients were at stage A and the OPN mRNA mean CT value was 1.49±0.38, 1.21±0.28 for stage B(17 patients), 1.11±0.29 for stage C(18 patients ),and 0.92±0.32 for stage D(2 patients). Here, SPP1 is linked to colorectal carcinoma.