The present study was carried out with the aim to determine whether SULT1E1 -64G/A, COMT Val158Met, ESR1 c.454−397 T/C and c.454−351 A/G genes are associated with ischemic stroke of the young and to further explore the gene-gene and gene-environment interactions for young ischemic stroke patients. Here, ESR1 is linked to ischemic stroke.