COMT and ischemic stroke: Among participants with Val/Val genotype, SULT1E1 -64G/A is the strongest risk factor, and the combination of COMT Val/Val genotype and SULT1E1 A/A genotype exhibited the highest risk of ischemic stroke with 73.5% patients rate (OR, 6.57; 95%CI, 2.55–16.94; p<0.0001) (Figure 2 and Table 4).