Our results revealed that the pro-angiogenic, AA-derived eicosanoids PGE2, 12-HETE, and 15-HETE, as well as the key inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), were dramatically reduced in B16 melanoma and LLC tumors treated with D6D-RNAi or SC-26196 (Figures 3B,4D). This evidence concerns the gene TNF and melanoma.