In the next model, we determined whether an inflammatory factor (defined by IL-6 and CRP), a vagal factor (defined by HFHRV and RMSSD under paced respiration at rest), and “insulin resistance”, “adiposity”, “dyslipidemia”, and “BP” factors (as defined above) could all be represented with a single common underlying factor (Figure 2). The gene discussed is CRP; the disease is metabolic syndrome.