On the same line, in acute lung infections caused by P. aeruginosa, a Gram-negative pathogen responsible of life-threatening infections in immunocompromised individuals and cystic fibrosis patients, Tir8/Sigirr-deficiency was associated to increased susceptibility in terms of mortality and bacterial load, and to exacerbated local and systemic production of pro-inflammatory cytokines and chemokines. Here, SIGIRR is linked to infection.