IL-1 plays a significant role in zymosan-induced arthritis model, and IL-1Ra reduced the disease severity in Tir8/Sigirr-deficient mice, but did not completely rescued the phenotype, suggesting that additional factors, including TLRs ligands, are driving pathology and are under Tir8/Sigirr control (Figure 3; Table 2). Here, SIGIRR is linked to arthritic joint disease.