IL1A and neoplasm: In addition, an inflammatory component is present in the microenvironment of most neoplastic tissues and includes the infiltration of white blood cells, prominently tumor-associated macrophages (TAM); the presence of inflammatory cytokines (e.g., TNFα, IL-1, IL-6, IL-23, IL-17, chemokines, such as CCL2); the occurrence of tissue remodeling and angiogenesis (Mantovani et al., 2008; Colotta et al., 2009; Biswas and Mantovani, 2010; Ben-Neriah and Karin, 2011).