The relevance in pathology of TIR8/SIGIRR expression in kidney has been demonstrated in different conditions, such as lupus nephritis (Lech et al., 2008, 2010; discussed above) and postischemic acute renal failure or kidney transplantation (Lech et al., 2009; Noris et al., 2009), conditions associated to TLRs activation by nucleosomes and DAMPs released during ischemic cell necrosis, respectively (Figure 3; Table 2). This evidence concerns the gene SIGIRR and acute kidney injury.