The relevance of genetic variants of the TIR8/SIGIRR gene in susceptibility to SLE was recently investigated in a large European-descent population, but the analysis was restricted to a single missense polymorphism (rs3210908), which results in the replacement of a glutamine (Gln) for arginine (Arg) at amino acid 312 (Q312R) and it did not reveal any association between TIR8/SIGIRR gene variants and SLE (Sanchez et al., 2012). The gene discussed is SIGIRR; the disease is systemic lupus erythematosus.