SIGIRR and renal fibrosis: In contrast, lack of Tir8/Sigirr did not affect the intrarenal mRNA expression of pro-inflammatory chemokines, profibrotic mediators, or markers of renal fibrosis after unilateral ureter obstruction, nor the number of intrarenal macrophages and myofibroblasts or tissue remodeling in post obstructive kidneys (Skuginna et al., 2011).