Akt-mTOR signaling is a critical pathway driving tumor initiation in the Apcmin/+ mouse, since it promotes cell cycle progression through posttranscriptional control of the key cell cycle regulators, such as Cyclin D1, cyclin E, and c-Mycand LOH of Apc (Aoki et al., 2003). This evidence concerns the gene AKT1 and neoplasm.