SIGIRR and acute lung injury: Finally, after endotoxin challenge, survival was reduced in Tir8/Sigirr-deficient mice on a BALB/c background (Wald et al., 2003), and overexpression of Tir8/Sigirr in lung epithelial cells suppressed the inflammatory reaction and improved the survival of BALB/c mice in a model of LPS-dependent Acute Lung Injury (Chen et al., 2011).