In dextran sodium sulfate (DSS) colitis model, Tir8/Sigirr-deficient mice exhibited a dramatic intestinal inflammation compared to wild type mice in terms of weight loss, intestinal bleeding, local tissue damage, and mortality, which was associated to increased leukocyte infiltration and pro-inflammatory cytokine, chemokine, and prostaglandin production (Garlanda et al., 2004; Xiao et al., 2007). This evidence concerns the gene SIGIRR and colitis.