FAS and Autoimmunity: Genetic approaches showed that Tir8/Sigirr-deficiency alone did not induce autoimmunity against DNA, however, the deficiency of Tir8/Sigirr in C57BL/6lpr/lpr mice, which develop delayed autoimmunity due to impaired Fas-induced apoptosis of autoreactive B and T cells, caused massive lymphoproliferation, peribronchial inflammation and mesangioproliferative glomerulonephritis (Lech et al., 2008).