On the same line, Tir8/Sigirr-deficiency caused increased susceptibility to lupus nephritis in a model, which mimics environmentally induced autoimmunity: intraperitoneal injection of hydrocarbon oil (pristane) causes persistent abundance of apoptotic peritoneal cells, chronic granulomatous peritonitis, ectopic lymphoid tissue formation, and evolution of antinuclear antibodies, immune complex disease, and lupus nephritis. Here, SIGIRR is linked to hyperinsulinemic hypoglycemia, familial, 4.