Surprisingly, although healthy controls and new-onset T1D patients exhibited a similar pattern of gene expression relationships, more correlative relationships of gene expression were identified in the long-term diabetic group than in healthy controls, such that the expression of CD3G, CD11b, S100A6, S100A9,S100A10, S100A11, or S100A13 correlated with a majority of the other genes analyzed in the study, regardless of their primary functional denotation in T-, B-, or myeloid cells. The gene discussed is CD3G; the disease is type 1 diabetes mellitus.