Behavioral and neurochemical studies support a role of galanin and NPY in mood disorders and GalR1-3 and NPYY1 receptors have been the receptors implicated in depression with GalR subtype specific antagonists and NPYY1 agonists having an antidepressant role (Lu et al., 2005; Lundstrom et al., 2005; Ishida et al., 2007; Jimenez-Vasquez et al., 2007; Fuxe et al., 2008). This evidence concerns the gene GAL and major depressive disorder.