In human and mouse, MFRP is expressed as a dicistronic transcript together with another gene, C1QTNF5/CTRP5 (complement-1q tumor necrosis factor-related protein 5), which is colocalized with MFRP in RPE and ciliary bodies and whose mutation was shown to cause late-onset retinal degeneration [17,18,20,22,23]. The gene discussed is C1QTNF5; the disease is late-onset retinal degeneration.