Several reports correlate mutations of membrane frizzled-related protein gene (MFRP, OMIM 606227) with a recessively inherited ocular syndrome characterized by the association of posterior microphthalmos (PM), retinitis pigmentosa (RP), foveoschisis, and optic nerve head (ONH) drusen [1–4]. This evidence concerns the gene MFRP and retinitis pigmentosa 1.