Given our findings that the prognosis of patients negative for HDAC1 and HDAC2 was significantly better than that those who were positive, and that HDAC2 expression is negatively correlated with apoptotic index, we designed siRNAs to knock down HDAC1 and HDAC2 and measured Axin expression and apoptosis in BE1 cells (a type of large cell lung carcinoma). The gene discussed is HDAC1; the disease is lung large cell carcinoma.