Normal lung tissues expressed higher levels of HDAC1 and HDAC2 than NSCLC tissues (positive rates of HDAC1 and HDAC2 in normal lung tissues are both 85.0%, 17/20, positive rate of HDAC1 in NSCLC tissues is 50.5%, 48/95 and positive rate of HDAC2 in NSCLC tissues is 48.4%, 46/95). The gene discussed is HDAC1; the disease is non-small cell lung carcinoma.