Combining our previous results showing that X-radiation upregulates Axin expression in some NSCLC tissues, we suggest that X-radiation may inhibit HDAC1 and HDAC2 expression and weaken the inhibitory effect of HDAC1 and HDAC2 on Axin, thereby upregulating Axin expression and inducing apoptosis of cancer cells. Here, AXIN1 is linked to non-small cell lung carcinoma.