There were no ≥grade-3 RT-related toxicities in patients treated with brain RT alone, but 4 patients experienced major toxicities (grade-3 acneiform rash in 2 patients, grade-3 oral mucositis in 1 patient, and grade-3 otitis media in 1 patient) during the course of concurrent EGFR TKI use. The gene discussed is EGFR; the disease is otitis media.