In this model of mixed insulin resistance, insulin acts through the mammalian target of rapamycin complex 1 to activate lipogenesis via a Srebp1c-dependent increase in lipogenic gene expression, whereas insulin-induced phosphorylation of the transcription factor forkhead box protein O1 is diminished such that gluconeogenic gene expression remains inappropriately active[33]. This evidence concerns the gene FOXO1 and Insulin resistance.