Further, whereas Ki-67 as a well-established prognostic marker in soft tissue sarcomas proved to be a superior predictor of overall survival[35], high EZH2 status – but not high H3K27me3 or high Ki-67 – was found to be predictive of distant metastasis in the MPSS+BPSS group. Here, EZH2 is linked to soft tissue sarcoma.