It is all the more intriguing why in certain tumors, such as carcinomas of the breast, ovary, and pancreas, no clear correlation between EZH2 expression and H3K27 trimethylation was found; rather, quite counterintuitively, both high EZH2 and low H3K27me3 turned out to have adverse prognostic significance[32]. This evidence concerns the gene EZH2 and breast carcinoma.