In line with the inhibitory property of the EBP1 gene, as previously demonstrated in cancers of glandular epithelial origin such as prostate[8,12,25], breast[14] and salivary[11], our current findings may suggest, at least in part, that a decrease of EBP1 contributes to the more malignant behavior of solid type than tubular histotype. Here, PA2G4 is linked to cancer.