In our previous study, we demonstrated that wild-type EBP1 gene transfer into human salivary adenoid cystic carcinoma cells significantly inhibits cell proliferation in in vitro assays, and most importantly, reduces tumor metastatic potential in an experimental metastatic mouse model[11], consistent with its inhibitory property identified in cancers of glandular epithelial origin such as prostate[12,13] and breast[14]. This evidence concerns the gene PA2G4 and cancer.