Since tumor attack by cytotoxic T lymphocytes and macrophages is mediated by the interaction of leukocyte function-associated antigen (LFA)-1 on lymphocytes with intercellular adhesion molecule (ICAM)-1 on the tumor surface[28,29], not surprisingly, reduced expression of ICAM-1 has been shown to promote immune evasion and metastasis, resulting in poor prognosis in patients with ACC[30]. This evidence concerns the gene ICAM1 and neoplasm.