In contrast, the proportion of positive EBP1 staining (98.49%) was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues (P=0.0402), with 17 cases (25.8%) scored as “+”, 3 cases (4.6%) as “++” and 45 cases (68.2%) as “+++”, indicating EBP1 is decreased in the progression of ACC. This evidence concerns the gene PA2G4 and adrenal cortex carcinoma.