In view of the reported changes in brain concentrations of phospholipids and PUFAs, and of neuronal loss in animal models of the metabolic syndrome [41-43], we hypothesized correlated disturbances in brain cPLA2 IVA and iPLA2 VIA expression, fatty acid concentrations, synaptic loss, BDNF, and PGE2, TXB2 and LXB4 concentrations. Here, BDNF is linked to metabolic syndrome.