SPRR2A and Bardet-Biedl syndrome: Other genes novel in this context and putatively important for Th1 cell differentiation and/or function include METRNL, (meteorin, glial cell differentiation regulator-like), associated with rare cases of Mild ring 17 syndrome [32], GLUL encoding a glutamine synthetase, and associated with neuronal disorders and atherosclerotic carotid plaques [33,34], MCTP2 (multiple C2 domains, trans membrane 2), BBS12 (Bardet-Biedl syndrome 12), STAG3 (stromal antigen 3), a meiotic gene, as well as PGAP1 (post-GPI attachment to proteins 1).