In another study on the chemotherapeutic effects of aspirin in colon cancer patients, a hazard ratio of 0.53 (for mortality) was observed in patients who did not use the drug prior to diagnosis and this value decreased to 0.39 for a subset of patients overexpressing cyclooxygenase-2 (COX-2) [5]. Here, PTGS2 is linked to malignant colon neoplasm.