Apart from its role in controlling malaria and other pathogenic disease, the IL-4 polymorphisms (-590T, -34T and intron-3 VNTR R2) have been found to be associated with end stage renal disease, multiple sclerosis, autoimmune Grave’s disease, polyarthritis, rheumatoid arthritis, asthma, rhinitis and atopic dermatitis [21], [26], [27], [28], [29]. The gene discussed is IL4; the disease is polyarticular arthritis.