IGHE and malaria: Several findings have shown association of -590T, -34T and intron-3 VNTR polymorphism R2 with high level of serum IL-4 and consequent high level of total IgG, IgE, anti-plasmodium IgG and IgE, and severity of infection in several populations of malaria endemic region across the globe [16], [17], [18], [19], [21], [22], [23], [24], [25], [37].