For example, actin-related protein 3 and tubulin α-1 chain were key gatekeeper proteins associated with cytoskeletal functions, whereas ADP-ribosylation factor-like 3, dihydropyrimidinase-related protein 2 and chaperonin containing TCP1 were identified in this role with iron deficiency. The gene discussed is ACTR3; the disease is Iron deficiency anemia.