The mean scores for both CD4+ (230.80±17.84 vs. 262.65±0.97 for Vα, P = 0.000; 167.62±6.19 vs. 171.63±4.52 for Vβ, P = 0.000) and CD8+ T cells (206.66±23.17 vs. 249.93±4.01, for Vα, P = 0.000; 150.42±12.44 vs. 167.99±6.51 for Vβ, P = 0.000) in TB patients were significantly lower than those of age-matched healthy controls. This evidence concerns the gene CD8A and tuberculosis.