IL-1β, TNFα and IL-8 expression was significantly enhanced in PMNs from SIRS (1.92±0.4, 1193±513.0, 1174±669.8) than control (0.35±0.03, 11.79±1.9, 5.150±1.2) subjects respectively (Fig. 3B). The gene discussed is TNF; the disease is systemic inflammatory response syndrome.