In summary, this study confirms in a hospital-based setting a substantial proportion of high-penetrance germ-line mutations in German patients with triple-negative breast cancer, with a preponderance of BRCA1 mutations over mutations in BRCA2 or PALB2, and with the exemplification of double heterozygosity for mutations in BRCA1 and PALB2. Triple-negative breast cancer should be considered as an additional criterion for future genetic counselling and diagnostic sequencing. The gene discussed is BRCA1; the disease is triple-negative breast carcinoma.