TFAM and neuropathy: In a recent study conducted using cybrid cells harboring NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) mutation, Wojewoda and colleagues demonstrated that selenium supplementation increased levels of NRF1 and nuclear accumulation of NRF2, caused no change in levels of PGC-1α and Tfam, and significantly lowered phospho-Akt levels [35].