The release of glutamate from glioma cells has been attributed to the lack of expression of GLT-1 glutamate transporter as well as mislocalization of another glutamate transporter GLAST to the nuclear membranes in glioma cells [23], which are the two predominant glutamate transporter subtypes expressed in glial cells of normal brain [24], [25]. This evidence concerns the gene SLC1A3 and glioma.