Reintroduction of Hugl1 into malignant melanoma cell lines resulted in increased adhesion, decreased invasive activity, downregulated matrix metalloproteinases (MMPs) and upregulated E-cadherin, supporting a role for Hugl1 in suppression of Epithelial to Mesenchymal Transition (EMT) [31]. This evidence concerns the gene LLGL1 and melanoma.