Based on chromosome 5q, 8p and 18q loci; in the BRAFwt/MSS cohort, 38/70 (54%) of CIN cancers had a concurrent p53 mutation, compared to only 4/20 (20%) of CIN-negative cancers (p = 0.01). The gene discussed is TP53; the disease is cervical squamous intraepithelial neoplasia.