Moreover, infection of Peripheral Blood Mononuclear Cells (PBMC) with HIV-1 resulted in a significant proteolytic degradation of GCN2 (45% reduction) and eIF4GI at 4 and 5 dpi, which was prevented in the presence of saquinavir (Figure 1E), strongly suggesting that the low levels of these proteins present in the cells were a consequence of HIV-1Pro cleavage. The gene discussed is EIF2AK4; the disease is infection.