ZNF469 and Fuchs endothelial corneal dystrophy: However, the PITX2 SNP rs17554590 and AVGR8 SNP rs1034200 showed modest associations with FECD severity (p = 0.0073 and 0.019, respectively), as did one marker in zinc-finger protein 469 (ZNF469) (p = 0.0081), after adjustment for CCT (Table 4).