Cunnington et al. (2010) revealed that the glioma risk allele SNP rs1063192-C is highly correlated with increased ANRIL expression, while the melanoma risk variant SNP rs1011970-T correlated with decreased expression of ANRIL. Chromosome 9p21 SNPs are known to correlate with susceptibility to glioma and malignant melanomas (Bishop et al., 2009; Shete et al., 2009; Wrensch et al., 2009). Other SNPs in the ANRIL locus have also been reported to be associated with its expression and involvement in susceptibility to coronary artery disease (Liu et al., 2009). The gene discussed is CDKN2B-AS1; the disease is central nervous system cancer.