A recent study on ciproxyfan in mice showed a reversal of methamphetamine-induced LA, reversal of downregulation of brain-derived neurotrophic factor (BDNF) and NMDA receptor subunit 1 genes in various regions of mice brain, reinforcing the interest of H3R antagonists in the treatment of cognitive deficits in psychotic patients (Motawaj and Arrang, 2011). Here, BDNF is linked to Cognitive impairment.