As a proof of concept, numerous data has accumulated from schizophrenia cases studied in both rodent models and in human subjects: increased H3R radioligand binding was found in dorsolateral PFC of schizophrenic subjects and bipolar subjects with psychotic symptoms (Jin et al., 2009) and antipsychotic-like profile of H3R antagonists observed in animal models. Here, HRH3 is linked to schizophrenia.