HRH3 and schizophrenia: The latter included improvement of prepulse inhibition (PPI) deficits in rodent schizophrenia models by H3R antagonists/antagonists such as ABT-239 in DBA/2 mice (Fox et al., 2005), pitolisant in Swiss mice (Ligneau et al., 2007), GSK-189254 in Wistar rats (Medhurst et al., 2007), and more recently irdabisant in rats (Raddatz et al., 2012).