HRH3 and Cognitive impairment: A recent study on ciproxyfan in mice showed a reversal of methamphetamine-induced LA, reversal of downregulation of brain-derived neurotrophic factor (BDNF) and NMDA receptor subunit 1 genes in various regions of mice brain, reinforcing the interest of H3R antagonists in the treatment of cognitive deficits in psychotic patients (Motawaj and Arrang, 2011).