HRH3 and Cognitive impairment: Thus, despite a strong AD related neurodegeneration of the TMN in its severe late stages, H3R densities are either preserved in the brains of amyloid overexpressing TASTPM transgenic mice as well as of AD patients as revealed by receptor binding data (Medhurst et al., 2007, 2009) or increased expression of H3R mRNA (in brains of female AD patients) is evidenced by PCR studies (Shan et al., 2012), signifying that they constitute an adequate target to improve the cognitive disorders encountered in AD.