In the present study, we showed that the genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT interacted with overweight/obesity to increase SBP levels, whereas the genotype of ACAT-1 CC interacted with overweight/obesity to decrease SBP levels. The gene discussed is SCARB1; the disease is obesity due to melanocortin 4 receptor deficiency.