In the case of the WWOX gene, reduced WWOX expression demonstrates a significant association with clinical Stage IV (p = 0.007), negative Progesterone Receptor (PR) status (p = 0.008) and shorter overall survival (p = 0.03), by means of immunoblotting and immunohistochemistry on normal ovaries and specific human ovarian carcinoma tissue microarrays (n = 444) [145]. The gene discussed is PGR; the disease is ovarian carcinoma.