Using an anti-FHIT polyclonal antibody in a standard immunohistochemical reaction, Lack of FHIT staining in a well-characterized cohort of 99 non-small-cell lung cancers (NSCLCs) was shown to be correlated with LOH at the FHIT 3p14.2 locus, and was inversely correlated with codon 12 mutations in K-ras. This evidence concerns the gene FHIT and non-small cell lung carcinoma.