Surprisingly, although FRA16D is a LOH site in breast, lung, esophageal, gastric, pancreatic carcinomas and lymphomas [47,54–59], WWOX mRNA is overexpressed in multiple breast cancer cell lines, including MCF-7, MDA-MB-453, SKBR3 and ZR-75-1 [54]. Here, WWOX is linked to breast carcinoma.