NQO1 and Alzheimer disease: In a mouse model of AD, decreased expression of mRNAs encoding Nrf2, NQO1, glutamate-cysteine ligase (GCL), the catalytic subunit (GCLC) and a modifier subunit (GCLM) correlates with increased accumulation of β-amyloid deposits [36] In vitro, Nrf2 activation protects neuronal cells against amyloid α peptide induced neurotoxicity, suggesting that activation of the Nrf2-ARE pathway might be a possible target for future therapies.