IL4 and colorectal carcinoma: By using an experimental model that mimics CD-associated CRC, in which mice received intrarectal administration of trinitrobenzene sulfonic acid (TNBS) and intraperitoneal injection of the carcinogen azoxymethane (AOM), these authors show that mice deficient in IFN-γ, develop significantly more neoplasms compared to wild-type mice and Th2-biased IL4−/− mice.