IFNG and neoplasm: Type I NKT cells, which express an invariant TCR-α chain (i.e., Vα24Jα18-Vβ11 in humans and Vα14Jα18-Vβ8 in mice), potentiate anti-tumor immunity by inducing IFN-γ expression [28], and tumor infiltration by Type I NKT cells in CRC patients has been positively correlated with disease-free survival [27].