Nonetheless, a considerable amount of work has been recently produced to show that mucosal inflammatory cell types can have effects either promoting (e.g., regulatory T cells (Tregs), Type 2 macrophages, CD4+ T helper (Th)-17 cells) or inhibiting (e.g., CD8+ T cells, Natural killer (NK) cells) CRC cell growth [5,6]. The gene discussed is CD4; the disease is colorectal carcinoma.