Presentation of tumor-specific antigens by antigen-presenting cells to CD8+ T cells results in release of different cytotoxic molecules (e.g., perforin, granzyme A, granzyme B, TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand) which can target and kill dysplastic and tumor cells [19]. The gene discussed is TNFSF10; the disease is neoplasm.