However, when Carabin-deficient mice are stimulated with a Toll-like Receptor 9 (TLR9) agonist (CpG-DNA), thereby mimicking a viral infection, we observe the production of anti-dsDNA antibodies and a lupus-like glomerulonephritis with immune deposits in a subgroup of mice. Here, TBC1D10C is linked to systemic lupus erythematosus.