Therefore, the aim of the study was to estimate the associations between the SNP at position −1607/−1608 of the MMP-1 gene and the SNP at position −1612/−1617 of the MMP-3 gene, and between the combinations of the genotypes created by the above-mentioned SNPs and the risk of pelvic organ prolapse. Here, MMP1 is linked to pelvic organ prolapse.