However, both poor CRF (OR 2.7, 95% CI: 1.2–6.1, p = 0.02) and overweight/obesity (BMI ≥ 85th percentile) (OR 2.5, 95% CI: 1.1–5.9, p = 0.03) were independent predictors of elevated salivary CRP secretion rates (≥ 75th percentile, ≥ 1276.39 pg/ml). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.