The current worldwide pandemic of childhood obesity and low levels of cardio-respiratory fitness (CRF) makes the understanding of inflammation and interventions to reduce inflammation, important areas of research.8,9 Obese children have higher levels of systemic CRP compared to children of normal weight, suggesting that chronic low-grade systemic inflammation is an early complication of childhood obesity.8 In addition, elevated systemic CRP in young children is a risk factor for the development of the metabolic syndrome.9 This evidence concerns the gene CRP and metabolic syndrome.