Interestingly, one of the major networks covers 9 DASE candidates, including cancer causative genes ZNF331 and USP6 and known breast cancer associated gene DMBT1, and most of them are downstream players of sex hormones (β-estradiol) and MMP pathways, suggesting their potential for being breast cancer risk alleles (Figure 3). The gene discussed is USP6; the disease is breast carcinoma.